Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2012
Measuring the effects of sevoflurane on electroencephalogram using sample entropy.
Monitoring the effect of anesthetic drugs on the neural system is a major ongoing challenge for anesthetists. During the past few years, several electroencephalogram (EEG)-based methods such as the response entropy (RE) as implemented in the Datex-Ohmeda M-Entropy Module have been proposed. In this paper, sample entropy is used to quantify the predictability of EEG series, which could provide an index to show the effect of sevoflurane anesthesia. The dose-response relation of sample entropy is compared with that of RE. ⋯ The results demonstrate that sample entropy can estimate the sevoflurane drug effect on the EEG more effectively than the commercial RE index with a stronger noise resistance.
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Acta Anaesthesiol Scand · Aug 2012
Desflurane-induced and ischaemic postconditioning against myocardial infarction are mediated by Pim-1 kinase.
Anaesthetic-induced (APOST) and ischaemic postconditioning (IPOST) against myocardial infarction are mediated via phosphatidylinositol-3-kinase/Akt. Pim-1 kinase is acting downstream of Akt and has recently been demonstrated to enhance cardiomyocyte survival. We tested the hypothesis that both APOST and IPOST are mediated by Pim-1 kinase. ⋯ These data suggest that Pim-1 kinase mediates both desflurane-induced postconditioning and IPOST in mice.
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Acta Anaesthesiol Scand · Aug 2012
Comparative StudyIsoflurane-induced post-conditioning in senescent hearts is attenuated by failure to activate reperfusion injury salvage kinase pathway.
We investigated the cardioprotective effects of isoflurane administered at the onset of reperfusion in senescent rat in vivo, and the activation of the reperfusion injury salvage kinase (RISK) pathway to address a possible mechanism underlying age-related differences. ⋯ We demonstrated that isoflurane post-conditions the heart in young but not in senescent rats. Failure to activate RISK pathway may contribute to attenuation of isoflurane-induced post-conditioning effect in senescent rats.