• Abdelouahid Tajar, John McBeth, David M Lee, Gary J Macfarlane, Ilpo T Huhtaniemi, Joseph D Finn, Gyorgy Bartfai, Steven Boonen, Felipe F Casanueva, Gianni Forti, Aleksander Giwercman, Thang S Han, Krzysztof Kula, Fernand Labrie, LeanMichael E JMEJ, Neil Pendleton, Margus Punab, Alan J Silman, Dirk Vanderschueren, Terence W O'Neill, WuFrederick C WFCW, and European Male Aging Study Group.
• Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford road, Manchester, M13 9PT, UK Epidemiology Group, Institute of Applied Health Sciences School of Medicine and Dentistry, University of Aberdeen, Aberdeen, Scotland, UK Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK Andrology Research Unit, Developmental & Regenerative Biomedicine Research Group, The University of Manchester, Manchester Academic Health Science Centre, Manchester Royal Infirmary, Manchester, UK Department of Obstetrics, Gynaecology and Andrology, Albert Szent-György Medical University, Szeged, Hungary Department of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatología Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Santiago de Compostela, Spain Endocrinology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy Reproductive Medicine Centre, Skåne University Hospital, University of Lund, Sweden Department of Endocrinology, University College London, London, UK Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland Laboratory of Molecular Endocrinology and Oncology, Laval University, Quebec City, Quebec, Canada Department of Human Nutrition, University of Glasgow, Glasgow, Scotland, UK School of Community Based Medicine, The University of Manchester, Salford Royal NHS Trust, Salford, UK Andrology Unit, United Laboratories of Tartu University Clinics, Tartu, Estonia Arthritis Research UK, Chesterfield, UK Department of Andrology and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
• Pain. 2011 Jul 1; 152 (7): 1495-1501.

AbstractThe aim of this study was to determine the association of hormone levels with the occurrence of musculoskeletal pain. Men ages 40 to 79 years were recruited from population registers in 8 European centres. Subjects were asked to complete a postal questionnaire, which enquired about lifestyle and the occurrence of musculoskeletal pain over the past month. Total testosterone (T), oestradiol (E2), luteinising hormone (LH), and follicle-stimulating hormone (FSH) were assayed from a fasting blood sample. The association between pain status and hormone levels was assessed using multinomial logistic regression with results expressed as relative risk ratios (RRR) and 95% confidence intervals (CI). A total of 3206 men had complete data on pain status. Of these, 8.7% reported chronic widespread pain (CWP), whereas 50% had some pain although not CWP and were classified as having some pain. T and E2 were not associated with musculoskeletal pain, whereas significant differences in LH and FSH levels were found between pain groups. After adjustment for age and other possible confounders, the association between pain status and both LH and FSH persisted. Compared with those in the lowest tertile of LH, those in the highest tertile were more likely to report some pain (vs no pain, RRR=1.28; 95% CI 1.09 to 1.50) and also CWP (vs no pain, RRR=1.51; 95% CI 1.10 to 2.07). Similar results were found for FSH. Gonadotrophins, but not sex steroid hormone levels, are associated with musculoskeletal pain in men.Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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