• Biull Eksp Biol Med · Sep 1993

    [The beta-carotene stimulation of cellular immunity reactions in mice].

    • I F Abronina, R Iu Ramanauskaĭte, T N Andreĭchuk, A N Rytenko, and S A Korostelev.
    • Biull Eksp Biol Med. 1993 Sep 1; 116 (9): 295-8.

    AbstractThe immunomodulating properties of synthetic beta-carotene were studied in C57Bl/6 and BALB/c mice using the tests of proliferative, cytotoxic and suppressor activity, and evaluating the adhesive capacity of macrophage lineage cells. Long-term feeding of C57Bl/6 mice with beta-carotene microgranules (0.1-0.5 mg of active substance per mouse) led to enhanced T cell proliferative response to ConA, which lasted for 15-45 days. Administration of beta-carotene oil solution to BALB/c mice previously immunized with alloantigens (0.17-0.34 mg of beta-carotene per mouse) enhanced T-cell cytotoxicity against L-929 and YAC-1 cells and macrophage cytotoxicity against L-929 cells. The treatment also reduced T-suppressor activity as shown in the assays of inhibition of the lymphocyte blast transformation reaction and mixed lymphocyte culture. The treatment with both preparations of beta-carotene enhanced the adhesive properties of macrophages and related cells, and induced the increased production of oxygen active radicals by these cells.

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