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- Alan Sariol and Stanley Perlman.
- Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.
- Immunity. 2020 Aug 18; 53 (2): 248-263.
AbstractA key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.Copyright © 2020 Elsevier Inc. All rights reserved.
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