• Shock · Jul 2021

    Review

    The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury and Sepsis: A Review of Pathophysiology.

    • Lauren S Kelly, Dijoia B Darden, Brittany P Fenner, Philip A Efron, and Alicia M Mohr.
    • Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
    • Shock. 2021 Jul 1; 56 (1): 304130-41.

    AbstractHematopoietic stem/progenitor cells (HSPC) have both unique and common responses following hemorrhage, injury, and sepsis. HSPCs from different lineages have a distinctive response to these "stress" signals. Inflammation, via the production of inflammatory factors, including cytokines, hormones, and interferons, has been demonstrated to impact the differentiation and function of HSPCs. In response to injury, hemorrhagic shock, and sepsis, cellular phenotypic changes and altered function occur, demonstrating the rapid response and potential adaptability of bone marrow hematopoietic cells. In this review, we summarize the pathophysiology of emergency myelopoiesis and the role of myeloid-derived suppressor cells, impaired erythropoiesis, as well as the mobilization of HSPCs from the bone marrow. Finally, we discuss potential therapeutic options to optimize HSPC function after severe trauma or infection.Copyright © 2020 by the Shock Society.

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