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- René Hage, Carolin Steinack, and Macé M Schuurmans.
- University Hospital Zurich, Division of Pulmonology, Zurich, Switzerland; University of Zurich, Faculty of Medicine, Zurich, Switzerland. Electronic address: rene.hage@usz.ch.
- Braz J Infect Dis. 2020 Jul 1; 24 (4): 365-367.
AbstractThe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause mild, moderate or severe disease (COVID-19). In severe disease, there is hyperinflammation causing severe symptoms. Severe COVID-19 is an immunological phenomenon, rather than a direct viral damage disease. Therapies for COVID-19 are all investigational therapies. In case of severe disease, treatment with a calcineurin inhibitor could be promising. In this article we explain the mechanisms of calcineurin inhibitor treatment for COVID-19, based on experiences seen in solid organ transplant recipients who suffered from COVID-19.Copyright © 2020 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.
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