• J. Thromb. Haemost. · Nov 2017

    Randomized Controlled Trial Multicenter Study Comparative Study

    Effect of late prophylaxis in hemophilia on joint status: a randomized trial.

    • M J Manco-Johnson, B Lundin, S Funk, C Peterfy, D Raunig, M Werk, C L Kempton, M T Reding, S Goranov, L Gercheva, L Rusen, V Uscatescu, M Pierdominici, S Engelen, J Pocoski, D Walker, and W Hong.
    • University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
    • J. Thromb. Haemost. 2017 Nov 1; 15 (11): 2115-2124.

    AbstractEssentials High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial of late/tertiary prophylaxis vs on-demand therapy. Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy.© 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

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