• Zhong Nan Da Xue Xue Bao Yi Xue Ban · Dec 2005

    [Advanced oxidation protein products in diabetic nephropathy patients and its relation with superoxide dismutase, glutathione peroxidase, neopterin].

    • Zhi-xian Wu, Yao-ming Xue, Chen-zhong Li, and Mei-ping Guan.
    • Department of Endocrinology, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350025, China.
    • Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Dec 1; 30 (6): 704-7.

    ObjectiveTo determine the changes of advanced oxidation protein products (AOPP) in diabetic nephropathy (DN) patients, as well as its relationship with superoxide dismutase (SOD), glutathione peroxidase (GPx) and neopterin (NPT).MethodsBy the concentration of urinary albumin excretion rate (UAER) and creatinine (Cr), 85 diabetes mellitus (DM) patients were divided into 4 groups as non-DN group (DM), early-staged DN group (DN3), significant DN group (DN4) and end-staged DN group (DN5). The concentration of the serum AOPP was measured by ameliorated method introduced by Wikto-Sarsat, while SOD by Xanthine oxidase test, GPx by [5,5'Dithio-bis (2-Nitrobenzoic aicd) ] (DTNB) reaction test and NPT by ELISA.ResultsAOPP in Group DN5 [(117.8 +/- 64.8) [micromol/L] and Group DN4 [ (80.0 +/- 23.0) micromol/L] were significantly higher than those in Group DM [(58.2 +/- 17.7) micromol/L]. There was no significant difference of AOPP between Group DN3 [(72.7 +/-17.2) micromol/L] and Group DM. Serum AOPP negatively correlated with SOD and GPx (r = -0.217 and -0.374 respectively, P < 0.05), while positively correlated with NPT (r = 0.499, P < 0.01).ConclusionDN patient has enhanced protein oxidation than DM patient, which is related to oxidative stress and chronic inflammation in DN.

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