• N Hyldig, J S Joergensen, C Wu, C Bille, C A Vinter, J A Sorensen, O Mogensen, R F Lamont, S Möller, and M Kruse.
• Department of Plastic Surgery, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
• BJOG. 2019 Apr 1; 126 (5): 619-627.

ObjectiveTo evaluate the cost-effectiveness of incisional negative pressure wound therapy (iNPWT) in preventing surgical site infection in obese women after caesarean section.DesignA cost-effectiveness analysis conducted alongside a clinical trial.SettingFive obstetric departments in Denmark.PopulationWomen with a pregestational body mass index (BMI) ≥30 kg/m2 .MethodWe used data from a randomised controlled trial of 876 obese women who underwent elective or emergency caesarean section and were subsequently treated with iNPWT (n = 432) or a standard dressing (n = 444). Costs were estimated using data from four Danish National Databases and analysed from a healthcare perspective with a time horizon of 3 months after birth.Main Outcome MeasuresCost-effectiveness based on incremental cost per surgical site infection avoided and per quality-adjusted life-year (QALY) gained.ResultsThe total healthcare costs per woman were €5793.60 for iNPWT and €5840.89 for standard dressings. Incisional NPWT was the dominant strategy because it was both less expensive and more effective; however, no statistically significant difference was found for costs or QALYs. At a willingness-to-pay threshold of €30,000, the probability of the intervention being cost-effective was 92.8%. A subgroup analysis stratifying by BMI shows that the cost saving of the intervention was mainly driven by the benefit to women with a pre-pregnancy BMI ≥35 kg/m2 .ConclusionIncisional NPWT appears to be cost saving compared with standard dressings but this finding is not statistically significant. The cost savings were primarily found in women with a pre-pregnancy BMI ≥35 kg/m2 .Tweetable AbstractProphylactic incisional NPWT reduces the risk of SSI after caesarean section and is probably dominant compared with standard dressings #healtheconomics.© 2018 Royal College of Obstetricians and Gynaecologists.

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