• Najmeh Sasani, Asma Kazemi, Mojtaba Rezaiyan, Ehsan Amiri-Ardekani, Masoumeh Akhlaghi, Siavash Babajafari, and Seyed Mohammad Mazloomi.
• Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
• Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14719.

Background And AimAnimal and human studies have indicated anti-diabetic effect of Asteraceae. The present study aimed to systematically review and analyse randomized controlled trials assessing the effect of Artemisia extract on glycemic status in patients with impaired glycemic control.MethodsWeb of Science, Cochrane library, EMBASE and PubMed databases were searched from the earliest possible date up to 7th October 2020.ResultsSix studies were included in the meta-analysis. Analysis showed that supplementation with Artemisia extract decreased homeostatic model assessment of insulin resistance (HOMA-IR) (-0.734, 95% CI: -1.236 to -0.232, P = .019) in comparison to placebo. However, reductions in fasting blood glucose (FBG) (-0.595, 95% CI: -1.566 to 0.376, P = .164), insulin (-0.322, 95% CI: -1.047 to 0.404, P = .286) and glycated haemoglobin (-0.106, 95% CI: -0.840 to 0.629, P = .678) were not statistically significant.ConclusionSupplementation with Artemisia extract may reduce HOMA-IR, but beneficial effects on other markers such as FBG requires further investigations.© 2021 John Wiley & Sons Ltd.

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