• BMJ · Jul 2003

    Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs.

    • Giuseppe Traversa, Clara Bianchi, Roberto Da Cas, Iosief Abraha, Francesca Menniti-Ippolito, and Mauro Venegoni.
    • Department of Epidemiology, National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy. giuseppe.traversa@iss.it
    • BMJ. 2003 Jul 5; 327 (7405): 18-22.

    ObjectiveTo estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs.DesignRetrospective cohort and nested case-control study.SettingUmbria region, Italy.Participants400 000 current, recent, and past users (almost 2 million prescriptions) of non-steroidal anti-inflammatory drugs between 1 January 1997 and 31 December 2001.Main Outcome MeasuresAdmissions to hospital for acute non-viral hepatitis and incidence of all hepatopathies and liver injury among users of nimesulide and other non-steroidal anti-inflammatory drugs.ResultsCurrent use of non-steroidal anti-inflammatory drugs was associated with a 1.4 (95% confidence interval 1.0 to 2.1) increased risk of hepatopathy compared with past use. In current users of nimesulide the rate ratio for all hepatopathies and more severe liver injury was 1.3 (0.7 to 2.3) and 1.9 (1.1 to 3.8), respectively.ConclusionThe risk of liver injury in patients taking nimesulide and other non-steroidal anti-inflammatory drugs is small.

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