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Emerging Infect. Dis. · May 2021
Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China.
- ChuDaniel K WDKW, HuiKenrie P YKPY, Haogao Gu, Ronald L W Ko, Pavithra Krishnan, Daisy Y M Ng, Gigi Y Z Liu, Carrie K C Wan, Man-Chun Cheung, Ka-Chun Ng, John M Nicholls, Dominic N C Tsang, Malik Peiris, ChanMichael C WMCW, and PoonLeo L MLLM.
- Emerging Infect. Dis. 2021 May 1; 27 (5): 1492-1495.
AbstractWe describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
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