• J Med Toxicol · Dec 2012

    Review

    Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.

    • Tammi Schaeffer.
    • Rocky Mountain Poison and Drug Center-Denver Health, Denver, CO, USA. Tammi.Schaeffer@rmpdc.org
    • J Med Toxicol. 2012 Dec 1;8(4):400-7.

    AbstractThe increased use of opioid pain medication has been mirrored by the increased misuse and abuse of these drugs. As part of a multidisciplinary approach to this epidemic, pharmaceutical companies, with the encouragement of the Food and Drug Administration, have increased the development of abuse-deterrent formulations. While all have the goal of treating pain while mitigating misuse and abuse, there are different technologies utilized to impart the abuse-deterrent properties. The goal of this paper is to review the basis of abuse-deterrent formulations, the different types and approaches of some of the abuse-deterrent products, and their current regulatory status in the USA.

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