• Internal medicine · Jan 2015

    Meta Analysis

    CC16 gene A38G polymorphism and susceptibility to asthma: an updated meta-analysis.

    • Dan Cheng, Honghong Di, Zheng Xue, and Guohua Zhen.
    • Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory of Respiratory Diseases, Ministry of Health, China.
    • Intern. Med. 2015 Jan 1; 54 (2): 155162155-62.

    ObjectiveTo comprehensively evaluate the association between the CC16 gene A38G polymorphism and the risk of asthma.MethodsStudies were retrieved from databases including PubMed, EMBASE, Web of Science and the Chinese Biomedical Literature Database according to the inclusive and exclusive criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.MaterialsFifteen case-control studies with 1,623 cases and 3,294 controls were recruited for the analysis of the association between the CC16 gene A38G polymorphism and the risk of asthma.ResultsThe overall ORs showed no significant associations between the CC16 gene A38G polymorphism and the risk of asthma (AA vs. GG: OR=1.04, 95%CI=0.86-1.25; AG vs. GG: OR=1.08, 95%CI=0.94-1.24; AA + AG vs. GG: OR=1.07, 95%CI=0.94-1.22; AA vs. AG + GG: OR=1.01, 95%CI=0.85-1.19; A vs. G: OR=1.04, 95%CI=0.95-1.14). Moreover, similar results were obtained in the subgroup analysis stratified by ethnicity (Asian: AG vs. GG: OR=1.02, 95%CI=0.87-1.21; Caucasian: AG vs. GG: OR=1.22, 95%CI=0.94-1.57) and age (Child: AG vs. GG: OR=1.21, 95%CI=0.84-1.74; Adult: AG vs. GG: OR=1.06, 95%CI=0.91-1.23).ConclusionCC16 gene A38G polymorphism is not associated with the risk of asthma.

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