• Krista Haines, Braylee Grisel, Laura Gorenshtein, and Paul E Wischmeyer.
• Division of Trauma and Critical Care and Acute Care Surgery, Department of Surgery, Duke University Medical Center.
• Curr Opin Crit Care. 2023 Aug 1; 29 (4): 293299293-299.

Purpose Of ReviewRecently, clinicians have shown interest in switching patients to nonsoybean-based intravenous lipid emulsion (ILE) formulas for parental nutrition (PN) due to adverse outcomes related to high Omega-6 content in soybean oil (SO) ILE's. This review summarizes recent literature on improved clinical outcomes with new Omega-6 lipid-sparing ILE's in PN management.Recent FindingsAlthough there is a paucity of large-scale studies directly comparing Omega-6 lipid sparing ILE's with SO-based lipid emulsion use in PN in ICU patients, there is strong translational and meta-analysis evidence to suggest that lipid formulations containing fish oil (FO) and/or olive oil (OO) have favorable effects on immune function and improve clinical outcomes in ICU populations.SummaryMore research is needed to directly compare omega-6-sparing PN formulas with FO and/or OO versus traditional SO ILE's. However, current evidence is promising for improved outcomes using newer ILE's including reduced infections, shorter lengths of stay, and reduced costs.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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