• Teresa Esposito, Martina Fregonese, Giulio Morettini, Paloma Carboni, Cecilia Tardioli, Antonio Messina, Rosanna Vaschetto, Della CorteFrancescoFDepartment of Translational Medicine, Università del Piemonte Orientale, Novara, Italy., Luigi Vetrugno, Paolo Navalesi, Edoardo De Robertis, Danila Azzolina, Annop Piriyapatsom, Mauro R Tucci, Hermann Wrigge, Philipp Simon, Elena Bignami, Salvatore M Maggiore, Rachele Simonte, and Gianmaria Cammarota.
• Department of Anesthesiology and Intensive Care, 'Maggiore della Carità' Hospital, Novara, Italy.
• J Clin Monit Comput. 2024 Feb 1; 38 (1): 8910089-100.

PurposeThis systematic review of randomized-controlled trials (RCTs) with meta-analyses aimed to compare the effects on intraoperative arterial oxygen tension to inspired oxygen fraction ratio (PaO2/FiO2), exerted by positive end-expiratory pressure (PEEP) individualized trough electrical impedance tomography (EIT) or esophageal pressure (Pes) assessment (intervention) vs. PEEP not tailored on EIT or Pes (control), in patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach.MethodsPUBMED®, EMBASE®, and Cochrane Controlled Clinical trials register were searched for observational studies and RCTs from inception to the end of August 2022. Inclusion criteria were: RCTs comparing PEEP titrated on EIT/Pes assessment vs. PEEP not individualized on EIT/Pes and reporting intraoperative PaO2/FiO2. Two authors independently extracted data from the enrolled investigations. Data are reported as mean difference and 95% confidence interval (CI).ResultsSix RCTs were included for a total of 240 patients undergoing general anesthesia for surgery, of whom 117 subjects in the intervention group and 123 subjects in the control group. The intraoperative mean PaO2/FiO2 was 69.6 (95%CI 32.-106.4 ) mmHg higher in the intervention group as compared with the control group with 81.4% between-study heterogeneity (p < 0.01). However, at meta-regression, the between-study heterogeneity diminished to 44.96% when data were moderated for body mass index (estimate 3.45, 95%CI 0.78-6.11, p = 0.011).ConclusionsIn patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach, PEEP personalized by EIT or Pes allowed the achievement of a better intraoperative oxygenation compared to PEEP not individualized through EIT or Pes.Prospero Registration NumberCRD 42021218306, 30/01/2023.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.

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