• Transl Res · Apr 2013

    Review

    Gene transfer for congestive heart failure: update 2013.

    • Tong Tang and H Kirk Hammond.
    • Department of Medicine, University of California San Diego, and VA San Diego Healthcare System, San Diego, Calif., USA.
    • Transl Res. 2013 Apr 1; 161 (4): 313320313-20.

    AbstractCongestive heart failure is a major cause of morbidity and mortality with increasing social and economic costs. There have been no new high impact therapeutic agents for this devastating disease for more than a decade. However, many pivotal regulators of cardiac function have been identified using cardiac-directed transgene expression and gene deletion in preclinical studies. Some of these increase function of the failing heart. Altering the expression of these pivotal regulators using gene transfer is now either being tested in clinical gene transfer trials, or soon will be. In this review, we summarize recent progress in cardiac gene transfer for clinical congestive heart failure.Copyright © 2013 Mosby, Inc. All rights reserved.

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