Lesson of the month 2: An unusual cause of depression in an older

Clin Med (Lond) · Oct 2018

Case Reports

Lesson of the month 2: An unusual cause of depression in an older man: Cushing's syndrome resulting from metastatic small cell cancer of the prostate.

This article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression.

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- Paul Kleinig and Patrick Russell.
- Southern Adelaide Local Health Network, Adelaide, Australia Paul.kleinig@sa.gov.au.
- Clin Med (Lond). 2018 Oct 1; 18 (5): 432434432-434.
AbstractThis article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression.© Royal College of Physicians 2018. All rights reserved.

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Lesson of the month 2: An unusual cause of depression in an older man: Cushing's syndrome resulting from metastatic small cell cancer of the prostate.

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