• Gabriela Nagai Ocamoto, Lucas Normando da Silva, Camila da Silva Rocha Tomaz, Matheus Toshio Hisatugu, Gustavo Frigieri, Danilo Cardim, Roberta Lins Gonçalves, Thiago Luiz Russo, and de AmorimRobson Luis OliveiraRLO0000-0003-2391-7519Health Sciences Postgraduation Program, Federal University of Amazonas, General Rodrigo Octavio Jordão Ramos Avenue, 1200, Manaus, Amazonas, 69067-005, Brazil..
• Braincare Desenvolvimento e Inovação Tecnológica S.A., Bruno Ruggiero Filho Avenue, 971, São Carlos, São Paulo, 13562-420, Brazil. gabriela.ocamoto@brain4.care.
• J Clin Monit Comput. 2024 Dec 1; 38 (6): 124912611249-1261.

PurposeAn FDA-approved non-invasive intracranial pressure (ICP) monitoring system enables the assessment of ICP waveforms by revealing and analyzing their morphological variations and parameters associated with intracranial compliance, such as the P2/P1 ratio and time-to-peak (TTP). The aim of this study is to characterize intracranial compliance in healthy volunteers across different age groups.MethodsHealthy participants, both sexes, aged from 9 to 74 years old were monitored for 5 min in the supine position at 0º. Age was stratified into 4 groups: children (≤ 7 years); young adults (18 ≤ age ≤ 44 years); middle-aged adults (45 ≤ age ≤ 64 years); older adults (≥ 65 years). The data obtained was the non-invasive ICP waveform, P2/P1 ratio and TTP.ResultsFrom December 2020 to February 2023, 188 volunteers were assessed, of whom 104 were male, with a median (interquartile range) age of 41 (29-51), and a median (interquartile range) body mass index of 25.09 (22.57-28.04). Men exhibited lower values compared to women for both the P2/P1 ratio and TTP (p < 0.001). There was a relative rise in both P2/P1 and TTP as age increased (p < 0.001).ConclusionsThe study revealed that the P2/P1 ratio and TTP are influenced by age and sex in healthy individuals, with men displaying lower values than women, and both ratios increasing with age. These findings suggest potential avenues for further research with larger and more diverse samples to establish reference values for comparison in various health conditions.Trial RegistrationBrazilian Registry of Clinical Trials (RBR-9nv2h42), retrospectively registered 05/24/2022. UTN: U1111-1266-8006.© 2024. The Author(s).

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