• J. Int. Med. Res. · Mar 2006

    Randomized Controlled Trial Comparative Study

    The effect of pre-operative lornoxicam and ketoprofen application on the morphine consumption of post-operative patient-controlled analgesia.

    • S Karaman, I Gunusen, M Uyar, and V Firat.
    • Department of Anaesthesiology and Reanimation, Ege University Faculty of Medicine, Ege University, Izmir, Turkey. skaraman@med.ege.edu.tr
    • J. Int. Med. Res. 2006 Mar 1;34(2):168-75.

    AbstractWe compared the efficacy of pre-operative intramuscular lornoxicam and ketoprofen for post-operative analgesia in patients undergoing abdominal hysterectomy. This randomized, double-blind, placebo-controlled, parallel-group study investigated 60 patients who received lornoxicam (group L, 8 mg), ketoprofen (group K, 100 mg) or saline (group C) 60 min before standard anaesthesia. All patients received patient-controlled analgesia (intravenous morphine) during the post-operative period. Visual analogue scale (VAS) scores recorded 2, 4, 6 and 12 h after surgery in groups L and K patients were significantly lower than in group C patients, and VAS scores at 2, 4 and 6 h in group L patients were significantly lower than those in group K patients. Morphine consumption in groups L and K was significantly lower than in group C. Pre-emptive administration of lornoxicam and ketoprofen effectively reduced post-operative pain and morphine consumption, and lornoxicam was more effective than ketoprofen in the early post-operative period.

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