• A Kararmaz, S Kaya, S Turhanoglu, and M A Ozyilmaz.
• Department of Anesthesiology, Dicle University Hospital, Diyarbakir, Turkey. alper@dicle.edu.tr
• Acta Anaesthesiol Scand. 2003 Feb 1;47(2):180-4.

BackgroundThe purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy.MethodsPatients were randomly assigned to one of three groups. Induction of anesthesia was performed with thiopentone 5 mg kg(-1) in Group I (n = 30), propofol 2 mg kg(-1) in Group II (n = 30), and propofol 3.5 mg kg(-1) in Group III (n = 30). Then succinylcholine 1 mg kg(-1) was administered to the patients for intubation.ResultsFasciculation was absent in 20% of Group III patients, and no vigorous fasciculation occurred in this group. Furthermore, the severity of fasciculation in Group III was significantly lower than in the other two groups (P = 0.01). Seventy per cent of patients had no myalgia in Group III, 39.2% in Group II and 37% in Group I (P = 0.007). Severity of myalgia was also significantly lower in Group III compared with the other two groups (P = 0.011). Post-operative creatine kinase levels were significantly higher than their baseline values in Groups I and II (P < 0.0001).ConclusionAdministration of propofol 3.5 mg kg-1 is effective in reducing fasciculations and myalgia after succinylcholine.Copyright Acta Anaesthesiologica Scandinavica 47 (2003)

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