• Pain · Dec 2013

    Review

    Bone cancer pain: Causes, consequences, and therapeutic opportunities.

    • Patrick Mantyh.
    • Department of Pharmacology, University of Arizona, 1501 North Campbell Avenue, LSN 560, PO Box 245050, Tucson, AZ 85724, USA. Electronic address: pmantyh@email.arizona.edu.
    • Pain. 2013 Dec 1;154 Suppl 1:S54-62.

    AbstractCommon cancers, including cancers of the breast, lung, and prostate, frequently metastasize to multiple bones where they can cause significant and life-altering pain. Similar to cancer itself, the factors that drive bone cancer pain evolve and change with disease progression. Once cancer cells have metastasized to bone, both the cancer cells and their associated stromal cells generate pain by releasing algogenic substances including protons, bradykinin, endothelins, prostaglandins, proteases, and tyrosine kinase activators. The release of these factors by cancer/stromal cells can induce sensitization and activation of nerve fibers that innervate the bone. Additionally, these factors can drive a remarkable increase in the number, size, and activity of bone-destroying osteoclasts, which can ultimately result in fracture of the tumor-bearing bone. Tumor growth in bone can also generate a neuropathic pain by directly injuring nerve fibers as well as inducing an active and highly pathological sprouting of both sensory and sympathetic nerve fibers that normally innervate the bone. This structural reorganization of sensory and sympathetic nerve fibers in the bone, combined with the cellular and neurochemical reorganization that occurs in the spinal cord and brain, appears to contribute to the peripheral and central sensitization that is common in advanced bone cancer pain. These mechanistic insights have begun to lead to advances in both how we understand and treat bone cancer pain.Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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