• Charles S Cleeland, Tito R Mendoza, Xin Shelley Wang, Jeanie F Woodruff, Guadalupe R Palos, Stephen P Richman, Arlene Nazario, Garrett R Lynch, Kai-Ping Liao, Gary M Mobley, and Charles Lu.
• The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ccleeland@mdanderson.org
• J. Clin. Oncol. 2011 Jul 20;29(21):2859-65.

PurposeWe compared risk factors for high disease- and treatment-related symptom burden over 15 weeks of therapy in medically underserved patients with advanced non-small-cell lung cancer and in patients treated at a tertiary cancer center.Patients And MethodsWe monitored symptom severity weekly during chemotherapy. Patients were recruited from a tertiary cancer center (n=101) and three public hospitals treating the medically underserved (n=80). We used a composite symptom-severity score and group-based trajectory analysis to form two groups: one with consistently more severe symptoms and another with less severe symptoms. We examined predictors of group membership.ResultsSeventy percent of the sample (n=126) reported low symptom-severity levels that decreased during therapy; 30% (n=55) had consistently severe symptoms throughout the study. In multivariate analysis, patients with good performance status being treated in public hospitals were significantly more likely than patients treated at the tertiary cancer center to be in the high-symptom group (odds ratio, 5.6; 95% CI, 2.1 to 14.6; P = .001) and to report significantly higher symptom interference (P = .001). Other univariate predictors of high-symptom group membership included variables associated with being medically underserved (eg, having less education, being single, and being nonwhite). No group differences by ethnicity were observed in the public hospitals. Medically underserved patients were less likely to receive adequate pain management.ConclusionPatients with advanced lung cancer and good performance status treated at public hospitals were more likely than those treated at a tertiary cancer center to experience substantial symptoms during chemotherapy.

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