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- Aikaterini Papadopoulou, Theophilus Luke Samuels, Asitha Dassanayake, Colin Spring, Johann Willers, and David Roy Uncles.
- From the Department of Anesthesia, Worthing Hospital, Worthing, United Kingdom.
- A A Case Rep. 2014 Apr 1;2(7):81-2.
AbstractProgressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare autoimmune neurological condition. Antibodies targeting glycine receptors (GlyR) have been implicated in PERM. Because GlyR activity is enhanced by inhaled anesthetic drugs at clinically relevant concentrations, there is a theoretical possibility that these drugs may be less effective in the presence of GlyR antibodies. We describe a case of general anesthesia in a patient with PERM and GlyR antibodies. This patient did not demonstrate a clinically significant alteration in the behavioral effects of anesthesia using induction of anesthesia with sevoflurane and maintenance of anesthesia using sevoflurane and nitrous oxide.
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