• J Clin Anesth · Feb 2019

    Review Meta Analysis

    Does spinal chloroprocaine pharmacokinetic profile actually translate into a clinical advantage in terms of clinical outcomes when compared to low-dose spinal bupivacaine? A systematic review and meta-analysis.

    Spinal 2-chloroprocaine has pharmacokinetic advantages over low dose bupivacaine that make it a useful choice for ambulatory surgery.

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    • Andrea Saporito, Marcello Ceppi, Andreas Perren, Davide La Regina, Stefano Cafarotti, Alain Borgeat, José Aguirre, Marc Van De Velde, and An Teunkens.
    • Anesthesia Department, Bellinzona Regional Hospital, (Switzerland).
    • J Clin Anesth. 2019 Feb 1; 52: 99-104.

    Study ObjectiveSpinal anesthesia is well suited for day-care surgery, however a persisting motor block after surgery can delay discharge. Among the new drugs available, chloroprocaine has been associated with a short onset time, and motor block duration and a quicker discharge. However, it is not clear if those outcomes are clinically significantly superior compared to those associated with the use of low-dose hyperbaric bupivacaine.DesignAim of the study was to determine if spinal 2-chloroprocaine was superior to low-dose spinal bupivacaine regarding the following outcomes: onset time, block duration, time to ambulation and time to discharge.Patients/InterventionsWe performed a systematic literature search of the last 30 years using PubMed Embase and the Cochrane Controlled Trials Register. We included only blinded, prospective trials comparing chloroprocaine with a low dose of bupivacaine for spinal anesthesia. Low dose bupivacaine was defined as a dose of 10 mg or less. Outcomes of interest were time to motor block regression (primary outcome), time to ambulation and time to discharge (secondary outcomes), as indirect indicators of a complete recovery after spinal anesthesia.Main ResultsCompared to a low dose bupivacaine, spinal 2-chloroprocaine was associated with significantly faster motor and sensory block regression (pMD = -57 min-140.3 min; P = 0.015 and <0.001 respectively), a significantly shorter time to ambulation and an earlier discharge (pMD = -84.6 min; P < 0.001 and pMD = -88.6 min and <0.001 respectively). Onset time did not differ between the two drugs (pMD = -1.1 min; P = 0.118).ConclusionsSpinal 2-chloroprocaine has a shorter motor block duration, a significantly quicker time to ambulation and time to discharge compared to low dose hyperbaric bupivacaine and may be advantageous when spinal anesthesia is performed for day case surgery.Copyright © 2018. Published by Elsevier Inc.

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    Spinal 2-chloroprocaine has pharmacokinetic advantages over low dose bupivacaine that make it a useful choice for ambulatory surgery.

    Daniel Jolley  Daniel Jolley
     
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