• Neurosurgery · Mar 2019

    Review

    Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Prophylactic Anticonvulsants in the Treatment of Adults with Metastatic Brain Tumors.

    • Clark C Chen, Robert C Rennert, and Jeffrey J Olson.
    • Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota.
    • Neurosurgery. 2019 Mar 1; 84 (3): E195E197E195-E197.

    Target PopulationsAdults with solid brain metastases who have not experienced a seizure.Question 1Do prophylactic antiepileptic drugs (AEDs) decrease the risk of seizures in nonsurgical patients with brain metastases who are otherwise seizure-free?RecommendationLevel 3: Prophylactic AEDs are not recommended for patients with brain metastases who did not undergo surgical resection and are otherwise seizure-free.Question 2Do prophylactic AEDs decrease the risk of seizures in patients with brain metastases and no prior history of seizures in the postoperative setting?RecommendationLevel 3: Routine postcraniotomy AED use for seizure-free patients with brain metastases is not recommended.The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_8.Copyright © 2019 by the Congress of Neurological Surgeons.

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