• Pain · Sep 2019

    Modulation of Brain Networks by Sumatriptan-Naproxen in the Inflammatory-Soup Migraine Model.

    • James Bishop, Lino Becerra, Gabi Barmettler, Pei-Ching Chang, Vanessa Kainz, Rami Burstein, and David Borsook.
    • Department of Anesthesia, Pain/Analgesia Imaging Neuroscience (PAIN) Group, Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
    • Pain. 2019 Sep 1; 160 (9): 2161-2171.

    AbstractMigraine is a debilitating condition; however, the pharmacological effects on central nervous system networks after successful therapy are poorly understood. Defining this neurocircuitry is critical to our understanding of the disorder and for the development of antimigraine drugs. Using an established inflammatory soup model of migraine-like pathophysiology (N = 12) compared with sham synthetic interstitial fluid migraine induction (N = 12), our aim was to evaluate changes in network-level functional connectivity after sumatriptan-naproxen infusion in awake, conscious rodents (Sprague-Dawley rats). Sumatriptan-naproxen infusion functional magnetic resonance imaging data were analyzed using an independent component analysis approach. Whole-brain analysis yielded significant between-group (inflammatory soup vs synthetic interstitial fluid) alterations in functional connectivity across the cerebellar, default mode, basal ganglia, autonomic, and salience networks. These results demonstrate the large-scale antimigraine effects of sumatriptan-naproxen co-administration after dural sensitization.

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