• Curr Pain Headache Rep · Jun 2003

    Review

    Pharmacotherapy of neuropathic low back pain.

    • Michael H Moskowitz.
    • Bay Area Pain Medical Associates, 311 Miller Avenue, Suite B, Mill Valley, CA 94941, USA. wolfhow1@ix.netcom.com
    • Curr Pain Headache Rep. 2003 Jun 1; 7 (3): 178-87.

    AbstractNeuropathic low back pain is examined from a structural standpoint, distinguishing processes that start from chronic inflammation and mechanical compromise and cross into the realm of neuropathy with primary neurogenic pathophysiology. The disease of chronic pain is discussed, examining peripheral and central changes in neuroanatomy, neurophysiology, and neuromolecular dynamics. The limitations of inadequate random controlled trials regarding long-term pharmacologic interventions are contrasted with excellent work in the basic science of chronic pain. Complex rational pharmacologic strategies for structural pathology, central pain processes, sites of medication action, and differing routes of administration are delineated.

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