• Neuroscience · Aug 2012

    Dopaminergic activity coincides with stimulus detection by the frontal lobe.

    • V de Lafuente and R Romo.
    • Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, QRO. 76230, Mexico. lafuente@unam.mx
    • Neuroscience. 2012 Aug 30;218:181-4.

    AbstractFor midbrain dopamine (DA) neurons to respond to sensory events, the presence of a stimulus must first be detected. Where is the signal that activates DA neurons coming from? Here we show that DA responses to a vibrotactile stimulus lag significantly behind those of the primary somatosensory cortex, but they arise with a latency that closely matches the onset of premotor neurons known to encode perceptual decisions. In agreement with previous findings, these data suggest that sensory evoked DA activity does not signal a stimulus physical presence but arises from the output of a perceptual decision.Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

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