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- Huaxin Zhu, Zelong Xing, Yeyu Zhao, Zheng Hao, and Meihua Li.
- Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang 330006, Jiangxi, China; Department of Preventive Medicine, Jiujiang University, No. 57, Xunyang East Road, Yuyang District, Jiujiang 332000, Jiangxi, China.
- Neuroscience. 2020 Jan 21; 428: 50-59.
AbstractCircular RNAs are an increasingly important topic in non-coding RNA biology, drawing considerable attention in recent years. Accumulating evidence suggests a critical role for circular RNAs in both early and latent stages of disease pathogenesis. Circular RNAs are abundantly expressed in brain tissue, with significant implications for neural development and disease progression. Disruption of these processes, including those seen in response to brain injury, can have serious consequences such as hemiplegia, aphasia, coma, and death. In this review, we describe the role of circular RNAs in the context of brain injury and explore the potential connection between circular RNAs, brain hypoxic ischemic injury, ischemia-reperfusion injury, and traumatic injury.Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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