Bosnian journal of basic medical sciences
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Acute kidney injury (AKI) is a common clinical syndrome with a broad aetiological profile. It complicates about 5% of hospital admissions and 30% of admissions to intensive care units (ICU). During last 20 years has been a significant change in the spectrum of severe AKI such that it is no longer mostly a single organ phenomenon but rather a complex multisystem clinical problem. ⋯ In this technique, classic dialysis hardware is used at low blood and dialysate flow rates, for prolonged period of time (6 to 12 h/day). SLED offers more haemodynamic stability, better correstion of hypervolaemia, and more adequate solue removal, compared with IHD. In conclusion, AKI in the ICU is increasingly a component of sepsis and MSOF, and the development of rational strategies for initiation, dosing, and effective delivery of RRT in this setting is among the greatest challenges facing nephrologists and intensivists today.