Molecular nutrition & food research
-
The stimulation of the free fatty acid receptor G-protein coupled receptor (GPR) 40 by GW9508 prevents bone loss by inhibiting osteoclast activity, both in vitro and in vivo. Here, we questioned whether the stimulation of the GPR40 receptor by dietary fatty acids may lead to the same beneficial effect on bone. ⋯ GPR40 contributes to counter ovariectomy-induced bone loss in a context of saturated fatty acid enrichment.