Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Opioid and opioid-like drug effects on whole-gut transit measured by scintigraphy.
We studied the effects of several drugs on gastrointestinal transit (tramadol HCl, acetaminophen with codeine and placebo) in a randomized, double-blind, crossover study. ⋯ Tramadol and APAP/C had no effect on gastric emptying or small bowel transit. At equianalgesic doses, tramadol caused less delay in colonic transit than APAP/C for 48 hr and delay in the GC agreed with the subjective complaints of constipation on both drugs.
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Comparative Study
Evaluation of lung ventilation and alveolar permeability in cirrhosis.
This study sought to evaluate lung ventilation and alveolar permeability (AP) in patients with cirrhosis of the liver. ⋯ Although lung ventilation is normal in most patients with cirrhosis of the liver (16 [55%] of 29 in the present study), the disease can predispose patients to AP damage; however, the degree of damage is not related to cirrhotic severity.
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Case Reports
Transient cranial neuropathy in prostatic cancer with bone metastases after rhenium-186-HEDP treatment.
Rhenium-186 (tin) hydroxyethylidene diphosphonate (186Re-HEDP), a bone-seeking radiopharmaceutical, has been successfully used in the treatment of patients with painful bone metastases. Toxicity is usually limited to reversible thrombocytopenia. ⋯ Both patients developed transient cranial neuropathy shortly after treatment with 186Re-HEDP. Transient neuropathy of cranial nerves needs to be distinguished from neurological abnormalities caused by disease progression.
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Comparative Study
Utility of technetium-99m-DTPA in determining regional ventilation.
The goal of this study was to determine the usefulness of radiolabeled aerosols in the assessment of regional ventilation in tracheotomized patients maintained on mechanical ventilation. ⋯ The lungs of patients maintained on mechanical ventilation can be imaged after the inhalation of 99mTc-DTPA from commercially available delivery kits, but the correlation between aerosol deposition and regional ventilation is poor. Better definition of ventilated lung segments is obtained when using a gas such as 81mKr because tracheal activity with the radiolabeled gas is minimized.