Chest
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IL-13 is a T-helper cell type 2 cytokine that plays an important role in the pathogenesis of asthma. IL-13 exposure for 14 days transforms cultured normal human bronchial epithelial cells to a goblet cell phenotype. We hypothesized that goblet cells would have a different pattern of cytokine secretion than ciliated airway cells. ⋯ Inflammatory mediators released from goblet cells may act in an autocrine and paracrine manner to enhance inflammation in diseases such as asthma in which there is increased IL-13 and goblet cell hyperplasia.
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Editorial Comment
Finding Common Ground: Professionalism and Acthar Prescribing Practices.