The Journal of allergy and clinical immunology
-
J. Allergy Clin. Immunol. · Aug 1994
Randomized Controlled Trial Comparative Study Clinical TrialThe preventive effect of nedocromil or furosemide alone or in combination on exercise-induced asthma in children.
Recent evidence suggests that inhaled nedocromil and furosemide are effective in preventing asthma by ultrasonically nebulized distilled water, allergen, and exercise. There are, however, no studies that compare the effects of these two drugs. The aim of this study was to investigate the effect of inhaled furosemide (30 mg), nedocromil (4 mg), the combination of these two drugs, and placebo aerosol in preventing exercise-induced asthma. ⋯ This study suggests that nedocromil and furosemide provide a comparable effect in preventing exercise-induced asthma in children. The combined administration of the two drugs significantly increases the protective effects, suggesting a potential therapeutic use.