The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2009
Multicenter StudyPhenotype of atopic dermatitis subjects with a history of eczema herpeticum.
A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum. ⋯ Subjects with AD in whom eczema herpeticum develops have more severe T(H)2-polarized disease with greater allergen sensitization and more commonly have a history of food allergy, asthma, or both. They are also much more likely to experience cutaneous infections with S. aureus or molluscum contagiosum.
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J. Allergy Clin. Immunol. · Aug 2009
Relevance of IgE binding to short peptides for the allergenic activity of food allergens.
Analysis of IgE antibody binding to epitopes provides information for food allergy diagnosis and management and construction of hypoallergenic candidate vaccines, but the contribution of sequential epitopes to functionally relevant IgE binding is not fully understood. ⋯ Peptides identified as major sequence epitopes on Pen a 1 and Ara h 2 show little contribution to the IgE binding of the allergens studied.
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J. Allergy Clin. Immunol. · Aug 2009
Randomized Controlled TrialAsthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence.
With the expanding effort to provide guidelines-based therapy to adolescents with asthma, attention must be directed to evaluating which factors predict future asthma control when guidelines-based management is applied. ⋯ Our findings demonstrate that the usual predictors of future disease activity have little predictive power when applied to a highly adherent population with persistent asthma that is receiving guidelines-based care. Thus, new predictors need to be identified that will be able to measure the continued fluctuation of disease that persists in highly adherent, well-treated populations such as the one studied.