Anesthesiology
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A wealth of evidence has demonstrated that sevoflurane preconditioning induces brain ischemic tolerance, but the mechanism remains poorly understood. This study was designed to investigate the role of canonical Notch signaling in the neuroprotection induced by sevoflurane preconditioning in a mouse model. ⋯ Sevoflurane preconditioning-induced protective effects against transient cerebral ischemic injuries are mediated by the activation of canonical Notch signaling pathway in mice.
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Editorial Comment
Sometimes you have to revisit the past to understand the present.
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Biography Historical Article Classical Article
Avoiding subarachnoid or intravascular injection of local anesthetics: a single test dose.