Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2006
Randomized Controlled TrialThe effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study.
The effect of melatonin on the intraoperative requirements for i.v.anesthetics has not been documented. We studied the effect of melatonin premedication on the propofol and thiopental dose-response curves for abolition of responses to verbal commands and eyelash stimulation. ⋯ Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia.
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Anesthesia and analgesia · Dec 2006
Randomized Controlled Trial Comparative StudyThe posterior approach to the sciatic nerve in the popliteal fossa: a comparison of single- versus double-injection technique.
We compared single-injection and double-injection of the sciatic nerve with nerve stimulation in the posterior popliteal approach using mepivacaine 1% in a prospective, randomized and single-blind study to evaluate effectiveness, delay of onset, and complications in patients undergoing foot and ankle surgery. In the single-injection group (Group S, n = 30), 25 mL of mepivacaine 1% was administered after eliciting foot inversion or plantar flexion. In the double-injection group (Group D, n = 30), 12.5 mL of the solution was injected after eversion or dorsiflexion and 12.5 mL after plantar flexion of the foot. ⋯ Complete analgesia of the deep peroneal nerve was achieved in 80% and 97% in Group S and D, respectively; P < 0.05. There were more paresthesias during block procedure in Group D (17% vs 40%) (P < 0.05). We conclude that double-nerve stimulation of the sciatic nerve gives similar complete onset times and overall success rate to single-nerve stimulation and more paresthesias during block performance.
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Anesthesia and analgesia · Dec 2006
Randomized Controlled TrialContinuous femoral nerve analgesia after unilateral total knee arthroplasty: stimulating versus nonstimulating catheters.
Continuous femoral analgesia provides extended pain relief and improved functional recovery for total knee arthroplasty (TKA). Stimulating catheters may allow more accurate placement of catheters. ⋯ The use of stimulating catheters in continuous femoral nerve blocks for TKA does not offer significant benefits over traditional nonstimulating catheters.
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Anesthesia and analgesia · Dec 2006
Randomized Controlled TrialSmall-dose ketamine reduces the pain of propofol injection.
I.v. injection of propofol during anesthetic induction induces pain. Ketamine has been shown to reduce injection pain. In this study, we established the optimal dose of ketamine to prevent the pain of injection with propofol. ⋯ Administration of ketamine 100 microg/kg immediately before propofol injection provided the optimal dose and timing to reduce propofol-induced pain on injection.