Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2006
Randomized Controlled TrialThe effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study.
The effect of melatonin on the intraoperative requirements for i.v.anesthetics has not been documented. We studied the effect of melatonin premedication on the propofol and thiopental dose-response curves for abolition of responses to verbal commands and eyelash stimulation. ⋯ Melatonin premedication significantly decreased the doses of both propofol and thiopental required to induce anesthesia.