Anesthesia and analgesia
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Anesthesia and analgesia · Jul 2010
The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix.
Nerve blocks of long duration are often desirable in perioperative and postoperative situations. The relationship between the duration of such blocks and the rate at which a local anesthetic is released is important to know for developing a localized drug delivery system that will optimize block duration. ⋯ Increasing initial lidocaine content proportionately increased the duration of functional sciatic nerve block. However, decreasing the release rate per se does not give a proportional increase in block duration. Instead, there seems to be an optimal, intermediate release rate for achieving the maximum duration of block.
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Anesthesia and analgesia · Jul 2010
Editorial CommentNeuromuscular block: views from the Western pacific.