Anesthesia and analgesia
-
Anesthesia and analgesia · Sep 2011
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized, open-label study of the safety and tolerability of fospropofol for patients requiring intubation and mechanical ventilation in the intensive care unit.
Current drugs for induction and maintenance of sedation in mechanically ventilated patients in the intensive care unit have limitations. Fospropofol, a prodrug of propofol, has not been studied as a sedative in the ICU setting. ⋯ This pilot study suggests that fospropofol, administered in either an infusion/bolus or infusion-only regimen, is tolerable and effective for short-term induction and maintenance of sedation in mechanically ventilated intensive care unit patients.
-
Anesthesia and analgesia · Sep 2011
Comparative StudyA comparison of different dosages of a continuous preperitoneal infusion and systemic administration of ropivacaine after laparotomy in rats.
To further explain the mechanisms of action involved in the analgesic effect of a local anesthetic wound infusion, we evaluated parietal and visceral sensitivity as well as indices of inflammation after laparotomy and administration of a local anesthetic. Ropivacaine was administered at different dosages by a continuous infusion using a multiholed catheter in the preperitoneal position or systemically in rats. ⋯ In the current study, high-dose ropivacaine administered via a preperitoneal infusion or systemic boluses had the same effect on mechanical and visceral sensitivity after laparotomy. Moreover, systemic administration was associated with an anti-inflammatory effect. The merits of the comparable benefit of systemic and high-dose preperitoneal infusion of ropivacaine need to be confirmed with further studies.
-
Anesthesia and analgesia · Sep 2011
Randomized Controlled Trial Comparative StudyLearning endotracheal intubation using a novel videolaryngoscope improves intubation skills of medical students.
Teaching endotracheal intubation to medical students is a task provided by many academic anesthesia departments. We tested the hypothesis that teaching with a novel videolaryngoscope improves students' intubation skills. ⋯ Education using a video system mounted into a traditional Macintosh blade improves intubation skills in medical students.
-
Anesthesia and analgesia · Sep 2011
Multicenter Study Comparative StudyThe effect of hospital size and surgical service on case cancellation in elective surgery: results from a prospective multicenter study.
Short-term case cancellation causes frustration for anesthesiologists, surgeons, and patients and leads to suboptimal use of operating room (OR) resources. In many facilities, >10% of all cases are cancelled on the day of surgery, thereby causing major problems for OR management and anesthesia departments. The effect of hospital type and service type on case cancellation rate is unclear. ⋯ When benchmarking cancellation rates among hospitals, comparisons should control for academic institutions having higher incidences of case cancellation than nonacademic hospitals and general surgery services having higher incidences than other services.