Anesthesia and analgesia
-
Anesthesia and analgesia · May 2017
Inhaled Remimazolam Potentiates Inhaled Remifentanil in Rodents.
Remimazolam is an ester-based short-acting benzodiazepine currently in clinical trials for IV administration. This study explored the feasibility of delivering remimazolam alone and as an adjunct to remifentanil via inhalation in rodent models. ⋯ Remimazolam can significantly potentiate the analgesic effect of remifentanil when concurrently delivered via inhalation.
-
Anesthesia and analgesia · May 2017
Comparative StudySevoflurane Posttreatment Attenuates Lung Injury Induced by Oleic Acid in Dogs.
In animal models, both sevoflurane and propofol protect against acute lung injury (ALI), especially when administered prior to ALI onset. We hypothesized that when compared to propofol, sevoflurane administration after the onset of acute respiratory distress syndrome would mitigate oleic acid (OA)-induced ALI in dogs. ⋯ When compared with propofol, sevoflurane attenuates OA-induced lung damage. However, despite this effect on lung histology and inflammation, sevoflurane worsened oxygenation in OA-induced ALI, possibly via inhibition of hypoxic pulmonary vasoconstriction.