Headache
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Randomized Controlled Trial Clinical Trial
Posterior hypothalamic and brainstem activation in hemicrania continua.
To determine the brain structures involved in mediating the pain of hemicrania continua using positron emission tomography. ⋯ This study demonstrated activations of various subcortical structures, in particular the posterior hypothalamus and the dorsal rostral pons. If posterior hypothalamic and brainstem activation are considered as markers of trigeminal autonomic headaches and migrainous syndromes, respectively, then the activation pattern demonstrated in hemicrania continua mirrors the clinical phenotype, with its overlap with trigeminal autonomic headaches and migraine.