Gut
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Multicenter Study
Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.
Only a minority of patients with chronic hepatitis C virus (HCV) infection develops severe liver fibrosis, a process that may be controlled by human genetic factors. ⋯ This identification of a cluster of four IFNGR2 variants strongly associated with fibrosis progression in chronic HCV infection underlines the role of IFNgamma in the development of liver fibrosis that may pave the way for new treatments.
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Multicenter Study
Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI study.
To address the role of anxiety and depression symptoms in altered pain processing in irritable bowel syndrome (IBS). ⋯ Altered central processing of visceral stimuli in IBS is at least in part mediated by symptoms of anxiety and depression, which may modulate the affective-motivational aspects of the pain response.
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Multicenter Study Clinical Trial
Sacral nerve stimulation for intractable constipation.
Traditional surgical procedures for intractable idiopathic constipation are associated with a variable outcome and substantial morbidity. The symptomatic response, physiological effect and effect on quality of life of sacral nerve stimulation (SNS) were evaluated in patients with constipation (slow transit and normal transit with impaired evacuation). ⋯ SNS is effective in the treatment of idiopathic slow and normal transit constipation resistant to conservative treatment. Clinical Trial Number NCT00200005.
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Multicenter Study
The early prediction of mortality in acute pancreatitis: a large population-based study.
Identification of patients at risk for mortality early in the course of acute pancreatitis (AP) is an important step in improving outcome. ⋯ A new mortality-based prognostic scoring system for use in AP has been derived and validated. The BISAP is a simple and accurate method for the early identification of patients at increased risk for in-hospital mortality.
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Multicenter Study
Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis.
To investigate differential intestinal gene expression in patients with ulcerative colitis and in controls. ⋯ Key findings are the expression gradient in the healthy adult colon and the involvement of novel gene families, as well as established candidate genes in the pathogenesis of ulcerative colitis.