Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jan 2005
Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study.
To examine the brain structural correlates of age at onset in patients with Alzheimer's disease. ⋯ Since genetic factors are believed to play a relevant pathogenetic role in EOAD and environmental factors in LOAD, genetic and environmental factors may differentially predispose the neocortical and limbic areas to the development of Alzheimer's neuropathology.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2005
Different patterns of medication change after subthalamic or pallidal stimulation for Parkinson's disease: target related effect or selection bias?
Bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) is favoured over bilateral globus pallidus internus (Gpi) DBS for symptomatic treatment of advanced Parkinson's disease (PD) due to the possibility of reducing medication, despite lack of definitive comparative evidence. ⋯ Differences in the patterns of medication change after Gpi and STN DBS may be partly due to a patient selection bias. Both procedures may be equally useful for different subgroups of patients with advanced PD, Gpi DBS especially for patients with lower threshold for dyskinesia.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2004
Unexpected decline in survival from amyotrophic lateral sclerosis/motor neurone disease.
To describe survival of 1226 Scottish adults with amyotrophic lateral sclerosis/motor neurone disease (ALS/MND). ⋯ We found an unexpected decline in survival over the 10 year period, despite controlling for potential confounding variables. We would be cautious about over-interpreting these observations and suggest that further research is required to confirm or refute these findings.
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J. Neurol. Neurosurg. Psychiatr. · Dec 2004
Multicenter Study Comparative StudyVariations in care and outcome in the first year after stroke: a Western and Central European perspective.
There are significant variations in the short term patterns of care and outcome after a first stroke in Europe. ⋯ There were significant variations in the pathways of care for stroke across European centres in the mid 1990s, which were associated with variation in outcome, and remain unexplained. Family support is more prevalent in southern Europe and service support more prevalent in the UK.