Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
Case ReportsBrain cysts associated with mutation in the Aristaless related homeobox gene, ARX.
The novel Aristaless related homeobox gene, ARX, is widely expressed in the brain and is thought to play a key role in the regulation of brain development. Neurological phenotypes caused by ARX mutations have recently started to unfold. ⋯ No retraction or expansion in neighbouring parenchyma was observed, there was no history of acute neurological impairment, and no risk factors for cerebrovascular disease were found. The lesions appeared to be congenital and represented benign developmental cysts, possibly caused by the ARX mutation.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
Clinical TrialPreoperative motor system brain mapping using positron emission tomography and statistical parametric mapping: hints on cortical reorganisation.
This study investigated the applicability of statistical parametric mapping (SPM) for analysing individual preoperative brain mapping studies in patients with cerebral mass lesions for neurosurgical planning. The study further investigated if hints on functional reorganisation processes can be found. ⋯ It is concluded that SPM provides an efficient method for analysing individual preoperative PET activation studies. Activations of the ipsilateral premotor cortices and contralateral cerebellum may indicate an enhanced recruitment of ipsilateral motor pathways evoked by functional reorganisation processes. However, this changed activation pattern was not necessarily associated with a better neurological status.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
Letter Case ReportsMultifocal myoclonus secondary to tranexamic acid.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2003
Biography Historical ArticleFridtjof Nansen (1861-1930).