Lancet
-
Review Meta Analysis
Detention of people with dangerous severe personality disorders: a systematic review.
UK government proposals to reduce the risks posed by people with "dangerous" severe personality disorders (DSPD) include a new legal framework for indeterminate detention. We aimed to establish the degree to which those operating the framework will be able to predict which people will act violently in the future. ⋯ In practice, the number of people that need to be detained is likely to be higher than we reported. Differences between populations in respect of which predictions are being made and the population on which an instrument was validated will reduce the accuracy of that instrument. Not all of the necessary information will always be available.
-
Randomized Controlled Trial Clinical Trial
Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial.
RTS,S/AS02 is a pre-erythrocytic malaria vaccine based on the circumsporozoite surface protein of Plasmodium falciparum fused to HBsAg, incorporating a new adjuvant (AS02). We did a randomised trial of the efficacy of RTS,S/AS02 against natural P. falciparum infection in semi-immune adult men in The Gambia. ⋯ RTS,S/AS02 is safe, immunogenic, and is the first pre-erythrocytic vaccine to show significant protection against natural P. falciparum infection.
-
Multicenter Study
Cardiopulmonary resuscitation directives on admission to intensive-care unit: an international observational study.
Resuscitation directives should be a sign of patient's preference. Our objective was to ascertain prevalence, predictors, and procurement pattern of cardiopulmonary resuscitation directives within 24 h of admission to the intensive-care unit (ICU). ⋯ Cardiopulmonary resuscitation directives established within 24 h of admission to ICU are uncommon. As well as clinical factors, timing and location of admission might determine rate and nature of resuscitation directives.