Lancet
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Review Meta Analysis
Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis.
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease. ⋯ This improvement in survival encourages the use of platinum-based combination chemotherapy for patients with invasive bladder cancer.