Lancet
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Randomized Controlled Trial
Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.
Helminth infections affect the human immune response. We investigated whether prenatal exposure to and treatment of maternal helminth infections affects development of an infant's immune response to immunisations and unrelated infections. ⋯ Wellcome Trust.
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Randomized Controlled Trial Multicenter Study
Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial.
Patients with follicular lymphoma can have long survival times, but disease progression typically occurs 3-5 years after initial treatment. We assessed the potential benefit of 2 years of rituximab maintenance after first-line treatment in patients with follicular lymphoma receiving a rituximab plus chemotherapy regimen. ⋯ Groupe d'Etude des Lymphomes de l'Adulte (GELA) and F Hoffmann-La Roche.
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Meta Analysis
Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.
Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer. Several lines of evidence suggest that aspirin might also reduce risk of other cancers, particularly of the gastrointestinal tract, but proof in man is lacking. We studied deaths due to cancer during and after randomised trials of daily aspirin versus control done originally for prevention of vascular events. ⋯ None.
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Biography Historical Article
Clare Gerada: Chair of UK's Royal College of General Practitioners.