Lancet
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Randomized Controlled Trial Multicenter Study
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.
Heart failure with preserved ejection fraction is associated with substantial morbidity and mortality, but effective treatments are lacking. We assessed the efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), in patients with this disorder. ⋯ Novartis.
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Multicenter Study
Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study.
The prevalence of extensively drug-resistant (XDR) tuberculosis is increasing due to the expanded use of second-line drugs in people with multidrug-resistant (MDR) disease. We prospectively assessed resistance to second-line antituberculosis drugs in eight countries. ⋯ US Agency for International Development, Centers for Disease Control and Prevention, National Institutes of Health/National Institute of Allergy and Infectious Diseases, and Korean Ministry of Health and Welfare.
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Memory disturbances frequently occur after brain damage, but can be associated with psychiatric illnesses as well. Amnesia--the most severe form of memory impairment--has several variants, including anterograde and retrograde amnesia, material-specific and modality-specific amnesia, and transient global amnesia. ⋯ Research into amnesia has increased exponentially, probably because of the availability of modern brain-imaging techniques. In line with the view that memory is not a unity but is organised into several systems, amnesia is described as a multifaceted disease with a frequently poor prognosis.